Welcome to the world of synthetic biology, where micro-organisms can be programmed to invade and destroy cancer cells.
By SCOTT
GOTTLIEB
It once seemed that the most profound feats stemming from DNA-based science
would spring from our ability to read and detect genes, which we call the
science of genomics. But the real opportunities lie in our ability to write
DNA, to synthesize new gene sequences and insert them into organisms, resulting
in brand-new biological functions. Printing novel DNA might open the way to
achievements once only conceivable in science fiction: designer bacteria that
can produce new chemicals, such as more efficient fuels, or synthetic versions
of our cells that make us resistant to the effects of radiation.
The first such genome was made in 2000 in an experiment where scientists
synthesized their own version of the hepatitis C virus so that they could alter
it and discover a way to disable the infection. Today it is possible to read
gene sequences into computers, where we can alter them and then print a modified
gene into living cells. In "Regenesis," a book exploring the science
of synthetic biology, George Church and Ed Regis imagine a world where
micro-organisms are capable of producing clean petroleum or detecting arsenic
in drinking water, where people sport genetic modifications that render their
bodies impervious to the flu, or where a synthetic organism can be programmed
to invade and destroy cancer cells.